What is Cosamin DS? Cosamin DS is the #1 Brand Recommended by Orthopedic Specialists. As a joint health supplement, Cosamin DS helps reduce joint pain and stiffness by using ingredients that are safe, effective, and easily absorbed. Cosamin DS is superior to all other brands and has been proven effective in published clinical studies. How Cosamin DS works The two main ingredients in Cosamin DS, FCHG49 glucosamine hydrochloride and TRH122 chondroitin sulfate, stimulate the production of cartilage. In younger, healthier individuals cartilage cells would normally accomplish this task. However, as one ages, cartilage cells die off and are not replaced. This starts a cycle of destruction in the cartilage. There are also enzymes present that degrade cartilage. Glucosamine hydrochloride stimulates cartilage production while chondroitin sulfate inhibits enzymes that break down cartilage. Chondroitin sulfate has been shown in clinical trials to slow the progression of cartilage deterioration as well as reduce joint pain.