Relieves Joint and Muscle Pain. Containing essential sulfur, MSM methylsulfonylmethane plays a crucial role in the formation of many tissues in the body, including collagen, a key component of cartilage and bone. Research suggests that MSM supplementation helps relieve chronic joint pain due to stress on cartilage and tendons, even as you age. Because MSM promotes the formation of Keratin, regular use enhances strong nails, smooth skin and thicker-looking, more lustrous hair. Available in tablets and powder for both men and women.