Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e net yield from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form - Found in all living cells, SAM-e is a metabolite of methionine an essential amino acid . SAM-e is a chiral molecule and consists of two forms S,S SAM-e and R,S SAM-e. The biologically active form is the S,S structure, while the R,S structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% S,S SAM-e, the highest active level available.
SAM-e has been clinically shown to have the following benefits -
Joint Strength - SAM-e supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue known as glycosaminoglycans GAGs , including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.
Brain Metabolism - SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine a component of lecithin .
Liver - SAM-e metabolism supports the synthesis of glutathione GSH and glutathione-dependent enzymes glutathione peroxidase and glutathione-S-transferase , which are substances important for liver function, including phase II detoxification.
Suggested Use As a dietary supplement take 1 tablet per day on an empty stomach - Or as directed by your healthcare professional.
Serving Size 1 Tablet
Servings Per Container 30
Amount Per Serving
% Daily Value***
S-Adenosyl Methionine from 800 mg of SAM-e tosylate disulfate
***Percent Daily Values are based on a 2,000 calorie diet
Other IngredientsCellulose, glyceryl behenate, magnesium stearate vegetable source , silicon dioxide, mannitol, sodium starch glycolate, and an enteric coating methacrylate copolymers, magnesium silicate, titanium dioxide, triethyl citrate, silicon dioxide and riboflavin .
Does Not ContainNo wheat, no gluten, no soybeans, no dairy,no egg, no fish/shellfish, no peanuts/tree nuts.
WarningsKeep out of reach of children. As with all dietary supplements, consult your healthcare professional before use. See product label for more information. Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors SSRIs and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinsons disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.