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Jarrow Formulas

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Jarrow Formulas SAMe 400mg 60 Tablet

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SAMe 400 mg 60 Tablet

Product Description

Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.

SAMe supports:

Joint Health

SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.

Brain Metabolism and Mood

SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes and precursor to acetylcholine, as well as neurotransmitters such as dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood.

Liver Functions

SAMe metabolism supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.

  • Enteric-Coated
  • Central biochemical building block
  • Bodys primary methyl donor
  • 68-80% Active S,S Form
  • Made Naturally By Fermentation
  • Individually Blister-Packed

Suggested Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.


Supplement Facts

Serving Size: 1 Tablet Servings Per Container: 60

Amount Per Serving % Daily Value***

S-Adenosyl Methionine (from 800 mg of SAMe Tosylate Disulfate) 400 mg *


* Daily Value (DV) not established.
***Percent Daily Values are based on a 2,000 calorie diet

Other Ingredients:Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, enteric coating (modified cellulose, magnesium silicate, triethyl citrate, riboflavin).


Does Not Contain:No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.


Warnings:Keep out of reach of children. As with all dietary supplements, consult your healthcare professional before use. See product label for more information. Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinsons disease, bi-polar disorder or manic depression should not use SAMe. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use. Keep out of reach of children.